北京大学 > 定量生物学中心 > 系统与合成生物学课题组

系统与合成生物学课题组

Main Content


 

  

Wu, Jiegen#; Chen, Baoqiang#; Liu, Yadi; Ma, Liang; Huang, Wen; Lin, Yihan*; Modulating gene regulation function by chemically controlled transcription factor clustering, Nature Communications, 2022, in press.(link)

 



 

  

Wu, Yan#; Xue, Lingfeng#; Huang, Wen#; Deng, Minghua; Lin, Yihan*; Profiling transcription factor activity dynamics using intronic reads in time-series transcriptome data, PLoS Computational Biology, 2022, 18(1):1-21.(link)

 


 

 

 

Xu, Shuhui#; Li, Kai#; Ma, Liang#; Zhang, Jianhan; Yoon, Shinae; Elowitz, Michael B.; Lin, Yihan*; Ratiometric RNA labeling allows dynamic multiplexed analysis of gene circuits in single cells, bioRxiv, 2021.(link)


 

 

Ma, Liang; Gao, Zeyue; Wu, Jiegen; Zhong, Bijunyao; Xie, Yuchen; Huang, Wen; Lin, Yihan*; Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics, Molecular Cell, 2021, 81(8):1682.(link)


 

 

 

Wu, Yan; Wu, Jiaqi; Deng, Minghua; Lin, Yihan*; Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs, Nature Communications, 2021, 12(1)(link)


 

 

 

Wu, Jiegen; Han, Xu; Zhai, Haotian; Yang, Tingyu; Lin, Yihan*; Evidence for rate‐dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells, Molecular Systems Biology, 2020, 16(5).(link)


 

Zhang, Jianhan#; Han, Xu#; Lin, Yihan*; Dissecting the regulation and function of ATP at the single-cell level, PLOS Biology, 2018, 16(12) (link) (Primer)


 

 

Martinez-Corral, R., Raimundez, E., Lin, Y., Elowitz, M. B., Garcia-Ojalvo, J.*, Self-amplifying pulsatile protein dynamics without positive feedback. Cell Systems 2018, 7(4), 453-462(link)


 

 

Park, J., Dies, M., Lin, Y., Hormoz, S., Smith-Unna, S. E., Quinodoz, S., Hernández-Jiménez, M. J., Garcia-Ojalvo, J., Locke, J. C. W., Elowitz., M. B., Molecular time sharing through dynamic pulsing in single cells. Cell Systems 2018, 6(2), 216-229 (link)


 

 

Yifat, Y, Sule, N, Lin, Y. & Scherer, N.F., (2018). Analysis and correction of errors in nanoscale particle tracking using the Single-pixel interior filling function (SPIFF) algorithm, Scientific Reports, 7, 16553.(link)


Prior to PKU:

Lin, Y. & Elowitz, M. B.*, (2016). Central dogma goes digital, Molecular Cell 61, 791-792 (link) (Perspective)

Lin, Y., Sohn, C., Dalal, C. K., Cai, L., & Elowitz, M. B.*, (2015). Combinatorial gene regulation by modulation of relative pulse timing, Nature 527 (7576): 54-58. (link)

Iyer-Biswas, S., Wright, C. S., Henry, J. T., Lo, K., Burov, S., Lin, Y., Crooks, G. E., Crosson, S., Dinner, A. R.*, & Scherer, N. F.*, (2014). Scaling laws governing stochastic growth and division of single bacterial cells, PNAS 114(45): 15912-15917.(link)

Dalal, C.K., Cai, L., Lin, Y., & Elowitz, M. B.*, (2014). “Pulsatile dynamics in the yeast proteome”, Current Biology 24(18): 2189-2194. (link)

Levine, J. H.#, Lin, Y.#, & Elowitz, M. B.*, (2013). Functional roles of pulsing in genetic circuits, Science 342(6163): 1193-1200.(link) (Review)

Lin, Y., Li, Y., Crosson, S., Dinner, A.R.*, & Scherer, N.F.*, (2012). Phase resetting reveals network dynamics underlying a bacterial cell cycle, PLoS Computational Biology 8(11): e1002778.(link)

Lin, Y., Crosson, S.*, & Scherer, N.F.*, (2010). Single-gene tuning of Caulobacter cell cycle period and noise, swarming motility, and surface adhesion, Molecular Systems Biology, 6: p. 445.(link)

Lin, Y., Zhao, T., Jian, X., Farooqui, Z., Qu, X., He, C., Dinner, A.R.*, & Scherer, N.F.*, (2009). Using the bias from flow to elucidate single DNA repair protein sliding and interactions with DNA, Biophysical Journal, 96: 1911-1917.(link)